Gut microbiota and thyroid diseases: a Mendelian randomization study
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Background Recent research indicates a potential association between gut flora and thyroid disease. Yet, the precise nature and direction of this hypothetical causal relationship remain elusive. This study aims to explore the potential causal association between gut microorganisms (GM) and various thyroid conditions, including Nontoxic goitre (NTG), Nontoxic multinodular goitre (NTMG), Thyrotoxicosis with toxic multinodular goitre (TTMG), and Thyroid Cancer (THCA). Methods Genome-wide association study (GWAS) statistics were pooled from MiBioGen and FinnGen for the assessment of gut flora and NTG/NTMG/TTMG/THCA. Various statistical methods including Inverse-Variance Weighting (IVW), MR-Egger regression, Weighted Median, Weighted Mode, Simple Mode, cML-MA, and MR-PRESSO were employed to assess the causal relationship between intestinal flora and NTG/NTMG/TTMG/THCA. Reverse Mendelian randomization (MR) analyses were conducted for intestinal flora identified as causally associated with NTG/NTMG/TTMG/THCA in the forward MR analysis. Furthermore, additional MR analysis was conducted after controlling for common confounders. Results Inverse-Variance Weighting revealed that the Rikenellaceae RC9 gut group (OR=1.144, 95% CI: 1.061–1.234, P
研究背景 近期研究表明肠道菌群与甲状腺疾病之间存在潜在关联，但该假设性因果关系的具体性质与作用方向仍尚不明确。本研究旨在探讨肠道微生物群（gut microorganisms, GM）与多种甲状腺疾病之间的潜在因果关联，涉及非毒性甲状腺肿（Nontoxic goitre, NTG）、非毒性多结节性甲状腺肿（Nontoxic multinodular goitre, NTMG）、毒性多结节性甲状腺肿伴甲状腺毒症（Thyrotoxicosis with toxic multinodular goitre, TTMG）以及甲状腺癌（Thyroid Cancer, THCA）。 研究方法 本研究从MiBioGen与FinnGen数据库中整合全基因组关联研究（Genome-wide association study, GWAS）数据，用于评估肠道菌群与NTG/NTMG/TTMG/THCA的关联。本研究采用多种统计方法评估肠道菌群与上述甲状腺疾病的因果关系，包括逆方差加权（Inverse-Variance Weighting, IVW）、MR-Egger回归、加权中位数法、加权众数法、简单众数法、cML-MA以及MR-PRESSO。针对正向孟德尔随机化（Mendelian randomization, MR）分析中鉴定出与NTG/NTMG/TTMG/THCA存在因果关联的肠道菌群，本研究开展了反向孟德尔随机化分析。此外，本研究在控制常见混杂因素后额外开展了孟德尔随机化分析。 研究结果 逆方差加权分析结果显示，理研菌科RC9肠道菌群组（Rikenellaceae RC9 gut group）的比值比（OR）=1.144，95%置信区间（CI）：1.061–1.234，P
