ToxicoDB: an integrated database to mine and visualize large-scale toxicogenomic datasets

This page links to the data associated with the publication "ToxicoDB: an integrated database to mine and visualize large-scale toxicogenomic datasets ". The data have been curated and analyzed using our open-source R package, ToxicoGx (cran.r-project.org/web/packages/ToxicoGx) and are available publicly in the ToxicoDB web application (www.toxicodb.ca). Please see the included DOIs below, or download the .csv file which contains the names, dates and DOIs of all datasets listed here. The TGGATES data was generated by Igarashi Y, Nakatsu N, Yamashita T, Ono A, Ohno Y, Urushidani T, Yamada H. Open TG-GATEs: a large-scale toxicogenomics database. Nucleic Acids Res [Internet]. 2015 Jan;43(Database issue):D921–7. Available from: http://dx.doi.org/10.1093/nar/gku955 PMCID: PMC4384023.<br> <br> Data: TGGATEs human (https://doi.org/10.5281/zenodo.3712283) TGGATEs rat (https://doi.org/10.5281/zenodo.3712292) This Drug Matrix data was generated by Ganter B, Snyder RD, Halbert DN, Lee MD. Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix database. Pharmacogenomics [Internet]. 2006 Oct;7(7):1025–1044. Available from: http://dx.doi.org/10.2217/14622416.7.7.1025 PMID: 17054413. Data: Drug Matrix (https://doi.org/10.5281/zenodo.3712247)本页面关联发表于论文《ToxicoDB：用于挖掘与可视化大规模毒理基因组数据集的整合数据库》（ToxicoDB: an integrated database to mine and visualize large-scale toxicogenomic datasets）的相关数据集。本数据集已通过我们开源的R语言工具包ToxicoGx（cran.r-project.org/web/packages/ToxicoGx）完成人工整理与分析，且可通过公开的ToxicoDB网页应用（www.toxicodb.ca）获取。请参阅下方提供的数字对象唯一标识符（DOI，Digital Object Identifier），或下载包含本页面所有数据集的名称、发布日期与DOI的.csv文件。<br><br>TGGATES数据集由Igarashi Y、Nakatsu N、Yamashita T、Ono A、Ohno Y、Urushidani T、Yamada H构建。其相关研究论文为《Open TG-GATEs：大规模毒理基因组学数据库》（Open TG-GATEs: a large-scale toxicogenomics database），发表于《核酸研究（网络版）》[Nucleic Acids Res [Internet]] 2015年1月；43(数据库特刊):D921–7，可通过http://dx.doi.org/10.1093/nar/gku955获取，PubMed Central编号（PMCID）：PMC4384023。相关数据集包括：TGGATES 人类样本数据集（https://doi.org/10.5281/zenodo.3712283）、TGGATES 大鼠样本数据集（https://doi.org/10.5281/zenodo.3712292）。<br><br>Drug Matrix数据集由Ganter B、Snyder RD、Halbert DN、Lee MD构建。其相关研究论文为《药物研发中的毒理基因组学：基于DrugMatrix数据库的化合物/类别依赖性效应机制分析》（Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix database），发表于《药物基因组学（网络版）》[Pharmacogenomics [Internet]] 2006年10月；7(7):1025–1044，可通过http://dx.doi.org/10.2217/14622416.7.7.1025获取，PubMed编号（PMID）：17054413。对应数据集为Drug Matrix数据集（https://doi.org/10.5281/zenodo.3712247）。