Lmna−/− mice display multiple tissue defects and die by 6–8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin
We used NGS of rna to understand transcriptome wide changes that occur in the left ventricles of pediatric idiopathic dilated cardiomyopathy patients. Overall design: Left ventricles were harvested fr
Mutations in the LMNA gene causes set of disorders collectively referred to as laminopathies that include dilated cardiomyopathy. Lamin A/C proteins a components of nuclear lamina forms distinct nucle