Research data for paper 'Proactive and retroactive interference with associative memory consolidation in the snail Lymnaea is time and circuit dependent'

Behavioural and electrophysiological data used in the figures for the paper by Crossley et al. published in Communications Biology June 2019 <br> <strong>Abstract for paper</strong> <br> Interference-based forgetting occurs when new information acquired either before or after a learning event attenuates memory expression (proactive and retroactive interference, respectively). Multiple learning events often occur in rapid succession, leading to competition between consolidating memories. However, it is unknown what factors determine which memory is remembered or forgotten. Here, we challenge the snail, <em>Lymnaea</em>, to acquire two consecutive similar or different memories and identify learning-induced changes in neurons of its well-characterized motor circuits. We show that when new learning takes place during a stable period of the original memory, proactive interference only occurs if the two consolidating memories engage the same circuit mechanisms. If different circuits are used, both memories survive. However, any new learning during a labile period of consolidation promotes retroactive interference and the acquisition of the new memory. Therefore, the effect of interference depends both on the timing of new learning and the underlying neuronal mechanisms. <br> <br>

Crossley等人于2019年6月发表于《Communications Biology》的论文配图所用的行为学与电生理数据集

**论文摘要**
基于干扰的遗忘是指，在学习事件发生前后获取的新信息会削弱记忆的表达（分别对应前摄干扰（proactive interference）与倒摄干扰（retroactive interference））。多个学习事件往往会快速连续发生，导致正在巩固的记忆之间产生竞争。但目前仍不清楚哪些因素决定了哪些记忆会被留存，哪些会被遗忘。本研究以椎实螺（*Lymnaea*）为实验对象，使其先后习得两种相似或不同的记忆，并对其已被充分表征的运动回路神经元中学习诱导的神经元变化进行鉴定。研究结果显示：若新学习发生在原始记忆的稳定巩固阶段，则仅当两种正在巩固的记忆调用相同的回路机制时，才会出现前摄干扰；若二者使用不同的回路，则两种记忆均可被保留。然而，若在记忆巩固的易变阶段开展任何新学习，则会引发倒摄干扰，并促进新记忆的习得。因此，干扰效应的产生同时取决于新学习的时间节点及其背后的神经元机制。