Effect of macular hole volume on postoperative central macular thickness

ABSTRACT Purpose: To evaluate the association between macular hole volume (MHV) and postoperative central macular thickness (CMT) using spectral-domain optical coherence tomography (SD-OCT). Methods: Thirty-three eyes of 30 patients with a large full-thickness idiopathic macular hole with or without vitreomacular traction who underwent surgical intervention were included in this cross-sectional study. Complete ophthalmological examination, including SD-OCT, was performed for all participants during the pre- and postoperative visits. MHV was preoperatively measured using SD-OCT, which captured the widest cross-sectional image of the hole. For normal distribution analysis of the data, the Kolmogorov-Smirnov test was performed, and for statistical analyses, chi-square, Student's t-test, Mann-Whitney U test, and Pearson's correlation coefficient test were performed. Results: Mean preoperative best-corrected visual acuity (BCVA) and MHV were found to be 0.99 ± 0.36 (range, 0.3-2.0) logMAR and 0.139 ± 0.076 (range, 0.004-0.318) mm3, respectively. Mean follow-up was 16.3 ± 14.3 (range, 3-50) months. No statistical correlations were found between MHV and postoperative BCVA (p=0.588) and between MHV and disease recurrence (p=0.544). A weak negative correlation existed between MHV and final CMT scores (p=0.04, r=-0.383). Conclusions: Greater MHV was found to be weakly associated with lower postoperative CMT scores.

摘要 目的：评估利用光谱域光学相干断层扫描（spectral-domain optical coherence tomography, SD-OCT）测得的黄斑孔体积（macular hole volume, MHV）与术后中心黄斑厚度（postoperative central macular thickness, CMT）之间的相关性。方法：本横断面研究纳入30例伴或不伴玻璃体黄斑牵引的大尺寸全层特发性黄斑孔患者的33只患眼，所有受试者均接受手术干预。所有参与者在术前及术后随访期间均完成包括SD-OCT在内的完整眼科检查。术前通过SD-OCT捕捉黄斑孔最宽横断面图像以测量MHV。针对数据的正态分布分析采用柯尔莫哥洛夫-斯米尔诺夫检验；统计学分析则采用卡方检验、学生t检验、曼-惠特尼U检验及皮尔逊相关系数检验。结果：术前平均最佳矫正视力（best-corrected visual acuity, BCVA）与MHV分别为0.99±0.36（范围：0.3~2.0）logMAR及0.139±0.076（范围：0.004~0.318）mm³。平均随访时长为16.3±14.3个月（范围：3~50个月）。未发现MHV与术后BCVA（p=0.588）及MHV与疾病复发（p=0.544）之间存在统计学相关性。MHV与最终CMT值之间存在弱负相关（p=0.04，r=-0.383）。结论：更大的MHV与更低的术后CMT值呈弱相关。