Cardioespiratory physiological perturbations after acute smoke-induced lung injury and during extracorporeal membrane oxygenation support in sheep

Background: Numerous successful therapies developed for human medicine involve animal experimentation. Animal studies that are focused solely on translational potential, may not sufficiently document unexpected outcomes. Considerable amounts of data from such studies could be used to advance veterinary science. For example, sheep are increasingly being used as models of intensive care and therefore, data arising from such models must be published. In this study, the hypothesis is that there is little information describing physiological data from sheep models of intensive care and the author aimed to analyse such data to provide biological information that is currently not available for sheep that received extracorporeal life support (ECLS) following acute smoke-induced lung injury.

Methods: Nineteen mechanically ventilated adult ewes undergoing intensive care during evaluation of a form of ECLS (treatment) for acute lung injury were used to collate clinical observations. Eight shee...

背景：众多应用于人类医学的成熟疗法均涉及动物实验。仅聚焦于转化研究潜力的动物研究，往往未能充分记录实验过程中的非预期结果。此类研究产生的大量数据，可用于推动兽医学的发展。例如，绵羊正日益被用作重症监护模型，因此此类模型产生的数据必须予以发表。本研究的研究假设为：当前针对重症监护绵羊模型的生理学数据描述较为匮乏；作者旨在分析此类数据，以填补急性烟雾诱导肺损伤后接受体外生命支持（extracorporeal life support, ECLS）的绵羊相关生物学信息空白。

方法：本研究纳入19只接受机械通气的成年母羊，在针对急性肺损伤的体外生命支持（extracorporeal life support, ECLS）治疗方案评估期间，收集其临床观察数据。共8只绵羊……