Gamma Interferon and Interleukin-10 Gene Expression in Synovial Tissues from Patients with Early Stages of Chlamydia-Associated Arthritis and Undifferentiated Oligoarthritis and from Healthy Volunteers

Genetically determined differences in interleukin-10 (IL-10) and gamma interferon (IFN-γ) responses in mice correlate with clearance of Chlamydia pneumonitis infection. We measured the synovial expression of IL-10 and IFN-γ and additional cytokine genes in patients who had recent-onset Chlamydia-associated arthritis (Chl-AA). IL-10 and IFN-γ mRNA were relatively abundant in recent-onset Chl-AA.