Red cell distribution width related to the severity of the disease in patients with AECOPD

This research aims to elucidate the association between red cell distribution width (RDW) and the severity of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). This retrospective study enrolled patients with AECOPD and healthy controls. A comprehensive meta-analysis was further conducted by systematically searching PubMed, Embase, and the Cochrane Library up to 27 April 2023. Univariate logistic regression analysis indicated that elevated RDW levels were significantly associated with AECOPD (<i>p</i> = 0.016). The pooled results yielded a diagnostic sensitivity of 0.76 (95% CI: 0.70–0.81) and specificity of 0.53 (95% CI: 0.38–0.68) for RDW in predicting AECOPD severity. Elevated RDW levels exhibit a linear positive correlation with AECOPD severity, further supported by meta-analysis.

本研究旨在阐明红细胞分布宽度（red cell distribution width, RDW）与慢性阻塞性肺疾病急性加重期（acute exacerbations of chronic obstructive pulmonary disease, AECOPD）严重程度之间的关联。本回顾性研究纳入了慢性阻塞性肺疾病急性加重期患者与健康对照者。此外，本研究通过系统检索截至2023年4月27日的PubMed、Embase及Cochrane Library数据库，开展了全面的荟萃分析。单因素logistic回归分析结果显示，红细胞分布宽度水平升高与慢性阻塞性肺疾病急性加重期显著相关（p=0.016）。荟萃合并结果表明，红细胞分布宽度预测慢性阻塞性肺疾病急性加重期严重程度的诊断灵敏度为0.76（95%置信区间：0.70~0.81），诊断特异度为0.53（95%置信区间：0.38~0.68）。红细胞分布宽度水平升高与慢性阻塞性肺疾病急性加重期严重程度呈线性正相关，该结论得到了荟萃分析的进一步支持。