Crystal structure of human DNA cross-link repair 1A in complex with quinoxalinedione inhibitor H2

Crystal structure of human DNA cross-link repair 1A in complex with quinoxalinedione inhibitor H2 Descriptor: 9-chloranyl-1,4-dihydropyrazino[2,3-c]quinoline-2,3-dione, DIMETHYL SULFOXIDE, DNA cross-link repair 1A protein, ... Authors: Newman, J.A, Yosaatmadja, Y, Baddock, H.T, Bielinski, M, von Delft, F, Bountra, C, McHugh, P.J, Schofield, C.J, Gileadi, O. Deposit date: 2023-02-02 Release date: 2024-02-21 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chem Sci, 15, 2024人源DNA交联修复1A蛋白与喹喔啉二酮类抑制剂H2复合物的晶体结构 描述符：9-氯-1,4-二氢吡嗪并[2,3-c]喹啉-2,3-二酮、二甲基亚砜、DNA交联修复1A蛋白等 作者：Newman, J.A、Yosaatmadja, Y、Baddock, H.T、Bielinski, M、von Delft, F、Bountra, C、McHugh, P.J、Schofield, C.J、Gileadi, O 保藏日期：2023-02-02 发布日期：2024-02-21 最后修改日期：2024-09-11 测试方法：X射线衍射（1.76 Å） 引用文献：《具有细胞活性的小分子抑制剂验证SNM1A DNA修复核酸酶可作为癌症靶点》，《化学科学》，第15卷，2024年