Summary statistics for genetic instruments used in multivariable MR analyses.

SNP: rsID of genetic instrument; expZ: trait and data set used as first/second/… exposure (e.g., if exp1 is ldl_mvp, LDL summary statistics from GLGC were used as the first exposure); expZ_beta: effect size estimate for trait expZ; expZ_se: standard error of effect size estimate for trait expZ; expZ_pval: P-value of effect size estimate for trait expZ; bc_beta: BC risk effect size estimate; bc_se: standard error of BC effect size estimate; bc_pval: P-value of BC effect size estimate; test: unique identifier for each 2, 3, or 5-exposure MVMR experiment included in this table. AaM, age at menarche; BC, breast cancer; BMI, body mass index; GLGC, Global Lipids Genetics Consortium; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MR, Mendelian randomization; MVMR, multivariable MR; MVP, Million Veteran Program; TC; total cholesterol; TG, triglyceride. (XLSX)单核苷酸多态性（Single Nucleotide Polymorphism, SNP）：作为遗传工具的rsID；expZ：用作第一、第二乃至更多暴露因素的性状与数据集（例如，若exp1为ldl_mvp，则将来自全球脂质遗传学联盟（Global Lipids Genetics Consortium, GLGC）的低密度脂蛋白（low-density lipoprotein, LDL）汇总统计量作为第一暴露因素）；expZ_beta：性状expZ的效应量估计值；expZ_se：性状expZ的效应量估计值的标准误；expZ_pval：性状expZ的效应量估计值的P值；bc_beta：乳腺癌（breast cancer, BC）风险的效应量估计值；bc_se：乳腺癌风险效应量估计值的标准误；bc_pval：乳腺癌风险效应量估计值的P值；test：本表所纳入的每项2暴露、3暴露或5暴露的多变量孟德尔随机化（multivariable Mendelian randomization, MVMR）实验的唯一标识符。其中，AaM为月经初潮年龄（age at menarche）；BC为乳腺癌（breast cancer）；BMI为身体质量指数（body mass index）；GLGC为全球脂质遗传学联盟（Global Lipids Genetics Consortium）；HDL为高密度脂蛋白（high-density lipoprotein）；LDL为低密度脂蛋白（low-density lipoprotein）；MR为孟德尔随机化（Mendelian randomization）；MVMR为多变量孟德尔随机化（multivariable MR）；MVP为百万老兵项目（Million Veteran Program）；TC为总胆固醇（total cholesterol）；TG为甘油三酯（triglyceride）。（XLSX格式）