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METTL3 and N6-methyladenosine Promotes Homologous Recombination Mediated Repair of DSBs by Facilitating R-loop Formation

NIAID Data Ecosystem2026-03-11 收录

DNA损伤修复

m6A表观遗传学

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE148573 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2020-07-14

DNA损伤修复

分子机制

Involvement of the synthesis sub-paths in the successful DNA repair in the non-disturbed model.

NIAID Data Ecosystem60

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

皮肤癌突变谱

DNA损伤修复

The UV component of sunlight is the major carcinogen involved in the etiology of skin cancers. We have studied the rare, hereditary syndrome xeroderma pigmentosum (XP), which is characterized by a ver

PubMed Central1993-11-15 更新40

Summarized fold change values by microarray results of the selected 9 CPD-dependent genes.

微阵列基因表达

DNA损伤修复

active PL: samples containing active CPD-photolyase, inactive PL: samples containing inactive CPD-photolyase.Summarized fold change values by microarray results of the selected 9 CPD-dependent genes.

Figshare2015-12-03 更新50

Data and code for analyzing DSB mobility

DNA损伤修复

肌动蛋白动力学

Double-strand breaks (DSBs) are critical lesions in genomic DNA, and their accurate repair is essential for maintaining genome stability. The nuclear actin cytoskeleton has been implicated in homology

DataCite Commons2025-10-22 更新40

METTL3 and N6-methyladenosine Promotes Homologous Recombination Mediated Repair of DSBs by Facilitating R-loop Formation

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