Univariable MR estimates for each lipid on early age onset PCa.

Genetically elevated LDL is significantly associated with early age onset PCa only through the IVW approach, whereas the pleiotropy-robust methods do not support this association. In addition, the weighted median approach supports a significant association for TG. Associations of P P ∈ (0.05,0.1], *P ∈ (0.01,0.05], **P ∈ (0.001,0.01], ***P ∈ (0,0.001]. IVW, inverse variance weighting; LDL, low-density lipoprotein; MR, Mendelian randomisation; PCa, prostate cancer; TG, triglyceride. (XLSX)仅通过逆方差加权（inverse variance weighting, IVW）法分析，方能揭示遗传升高的低密度脂蛋白（low-density lipoprotein, LDL）水平与早发性前列腺癌（prostate cancer, PCa）之间的显著关联；而稳健多效性方法则无法支持该关联。此外，加权中位数法可证实甘油三酯（triglyceride, TG）存在显著关联。关联的显著性标注规则如下：P值∈(0.05, 0.1]、*P值∈(0.01, 0.05]、**P值∈(0.001, 0.01]、***P值∈(0, 0.001]。术语注释：逆方差加权（inverse variance weighting, IVW）、低密度脂蛋白（low-density lipoprotein, LDL）、孟德尔随机化（Mendelian randomisation, MR）、前列腺癌（prostate cancer, PCa）、甘油三酯（triglyceride, TG）。(XLSX)