Crystal structure of human alpha-L-iduronidase complex with [2R,3R,4R,5S]-2-carboxy-3,4,5-trihydroxy-piperidine

Crystal structure of human alpha-L-iduronidase complex with [2R,3R,4R,5S]-2-carboxy-3,4,5-trihydroxy-piperidine Descriptor: (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Bie, H, Yin, J, He, X, Kermode, A.R, Goddard-Borger, E.D, Withers, S.G, James, M.N.G. Deposit date: 2013-04-29 Release date: 2013-09-18 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.701 Å) Cite: Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase. Nat.Chem.Biol., 9, 2013

人源α-L-艾杜糖醛酸酶（alpha-L-iduronidase）与[2R,3R,4R,5S]-2-羧基-3,4,5-三羟基哌啶的复合物晶体结构
配体描述：(2R,3R,4R,5S)-3,4,5-三羟基哌啶-2-羧酸、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等
作者：Bie H、Yin J、He X、Kermode A.R.、Goddard-Borger E.D.、Withers S.G.、James M.N.G.
提交日期：2013-04-29
发布日期：2013-09-18
最后更新日期：2024-10-16
实验方法：X射线衍射（分辨率2.701埃）
引用文献：《基于α-L-艾杜糖醛酸酶的结构与功能揭示黏多糖贮积症I型的机制》，《自然·化学生物学》（Nat.Chem.Biol.），第9卷，2013年