Pan-cancer Proteomics Analysis to Identify Tumor-Enriched and Highly Expressed Cell Surface Antigens as Potential Targets for Cancer Therapeutics
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CPTAC PAN-cancer Data Repository Welcome to the CPTAC PAN-cancer Data Repository! This repository serves as a data repository for the CPTAC PAN-cancer effort, which focuses on cancer target discovery. It contains various data sets related to protein abundance estimation, derived TMT-TPA, iBAQ, iBAQ-derived copy number, and differential protein expression for CPTAC ten indications. ## Contents The repository includes the following data: - FragPipe Output: Protein abundance estimation data generated using the FragPipe software.<br> - Derived TMT-TPA: Data derived from Tandem Mass Tag (TMT) based Total Protein Approach (TPA).<br> - iBAQ: Data representing intensity-based absolute quantification (iBAQ) of proteins.<br> - iBAQ-derived Copy Number: Data derived from iBAQ analysis for copy number estimation.<br> - Differential Protein Expression: Data indicating differential expression of proteins between tumor and NAT. ## Data Organization The data in this repository is organized in a structured manner to facilitate easy access and navigation. The repository structure is as follows: FragPipe/<br> [fragpipe_data_files]<br> Derived_TMT_TPA/<br> [derived_tmt_tpa_data_files]<br> iBAQ/<br> [ibaq_data_files]<br> iBAQ-derived_copy_number/<br> [ibaq_copy_number_data_files]<br> Differential_protein_expression/<br> [differential_expression_data_files]
CPTAC泛癌数据仓库 欢迎来到CPTAC泛癌数据仓库！本仓库为聚焦癌症靶点发现的CPTAC泛癌研究项目提供数据存储服务，收录了与CPTAC十大适应症相关的蛋白质丰度估算、衍生化TMT-TPA、iBAQ（intensity-based absolute quantification）、iBAQ衍生拷贝数以及差异蛋白质表达等多类数据集。 ## 数据集内容 本仓库包含以下数据： - FragPipe 输出结果：使用FragPipe软件生成的蛋白质丰度估算数据。 - 衍生化TMT-TPA：基于串联质量标签（Tandem Mass Tag, TMT）的总蛋白质定量法（Total Protein Approach, TPA）衍生得到的数据。 - iBAQ（intensity-based absolute quantification）：蛋白质强度绝对定量数据。 - iBAQ衍生拷贝数：通过iBAQ分析得到的拷贝数估算数据。 - 差异蛋白质表达：肿瘤与正常相邻组织（Normal Adjacent Tissue, NAT）之间的蛋白质差异表达数据。 ## 数据组织 本仓库中的数据采用结构化方式组织，便于快速访问与导航浏览。仓库目录结构如下： FragPipe/ [fragpipe_data_files] Derived_TMT_TPA/ [derived_tmt_tpa_data_files] iBAQ/ [ibaq_data_files] iBAQ-derived_copy_number/ [ibaq_copy_number_data_files] Differential_protein_expression/ [differential_expression_data_files]
