Research Data Supporting Biomechanical and Compositional Changes in the Murine Uterus with Age

The uterus is a hollow, fibromuscular organ involved in physiological processes such as menstruation and pregnancy. The content and organization of extracellular matrix constituents such as fibrillar collagen dictates passive (non-contractile) biomechanical tissue function; however, how extracellular matrix composition and biomechanical function change with age in the uterus remains unknown. This study utilizes Raman spectroscopy coupled with biaxial inflation testing to investigate changes in the murine uterus with age (2-3 months, 4-6 months, 10-12 months, and 20-24 months).

子宫是一种中空的纤维肌性器官，参与月经、妊娠等生理过程。细胞外基质(extracellular matrix)的组分（如纤维型胶原(fibrillar collagen)）的含量与排布决定了组织的被动（非收缩性）生物力学功能；然而，子宫细胞外基质组成与生物力学功能如何随年龄变化，目前仍不明确。本研究采用拉曼光谱(Raman spectroscopy)结合双轴充气测试技术，探究不同年龄段（2~3月龄、4~6月龄、10~12月龄及20~24月龄）小鼠子宫的年龄相关变化。