Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

CUT&RUN samples using anti-H3K27ac, H3.3, H3K27me3, H3K4me, H3K4me3 in resting (0h) and LPS stimulated (1h) bone marrow derived macrophages. HiC in resting BMDMs (BMDM_0_merged.hic)采用抗H3K27ac、H3.3、H3K27me3、H3K4me、H3K4me3抗体，从静息状态（0小时）与脂多糖（Lipopolysaccharide, LPS）刺激1小时的骨髓来源巨噬细胞（bone marrow derived macrophages, BMDM）中获取的CUT&RUN样本。 静息状态骨髓来源巨噬细胞的高通量染色体构象捕获（Hi-C）测序数据（文件名为BMDM_0_merged.hic）