EEG data repository

Rhythmic Auditory Stimulation(RAS) has been shown to be of help in an effective gait training of people with idiopathic Parkinson’s disease(PD).The cerebellum may play an important role in RAS aftereffects by compensating the detrimental internal clock for automatic and rhythmic motricity. However, the neurophysiological mechanisms underlying RAS aftereffects are still poorly understood. In the present study, we tested the contribution of the cerebellum to RAS-based gait training aftereffects in people with PD by examining cerebellum-cerebral connectivity indices using standard EEG recording. We enrolled 50 patients with PD who were randomly assigned to two different modalities of treadmill gait training using GaitTrainer3 with and without RAS (non_RAS) during an 8-week training program. We measured clinical and kinematic gait indices and electrophysiological data(standard EEG recording during walking on GaitTrainer3) of both the gait trainings. We found that the greater improvement in gait performance following RAS than non_RAS training, as per clinical and kinematic assessment, was paralleled by a more evident reshape of cerebellum-brain functional connectivity with regard to specific brain areas(pre-motor, sensorimotor and temporal cortices) and gait-cycle phases(mainly 25-75% of the gait cycle duration).These findings suggest that the cerebellum mediates the reshape of sensorimotor rhythms and fronto-centroparietal connectivity in relation to specific gait-cycle phases. This may be consistent with a recovery of the internal timing mechanisms generating and controlling motor rhythmicity, eventually improving gait performance. The precise definition of the cerebellar role to gait functional recovery in people with PD may be crucial to create patient-tailored rehabilitative approaches. The data deposited are related to the time course of the local maxima of the regions of interest (ROIs) showing functional activation at each of the gait cycle phases (0-25, 25-50, 50-75, and 75-100%), group (NMT and non-NMT), and time of assessment (TPRE and TPOST). Activity is shown for the maximum amplitude vertex within each ROI during the gait epoch.

节律性听觉刺激（Rhythmic Auditory Stimulation, RAS）已被证实可有效辅助特发性帕金森病（idiopathic Parkinson’s disease, PD）患者的步态训练。小脑或可通过补偿自动化与节律性运动功能中受损的内部时钟机制，在RAS的后续效应中发挥重要调控作用。然而，RAS后续效应背后的神经生理机制仍不甚明确。本研究通过标准脑电图（electroencephalogram, EEG）记录分析小脑-大脑连接指数，探究了PD患者接受基于RAS的步态训练后，小脑对其后续效应的贡献。我们招募了50名PD患者，将其随机分为两组，在为期8周的训练计划中，分别使用GaitTrainer3设备开展带RAS与不带RAS（非RAS组）的跑步机步态训练。我们采集并分析了两组步态训练的临床步态指标、运动学步态参数以及电生理数据（在GaitTrainer3上行走时的标准EEG记录）。结果显示，相较于非RAS训练，RAS训练后患者的步态性能提升更为显著，临床与运动学评估结果一致；与此同时，针对特定脑区（运动前皮层pre-motor、感觉运动皮层sensorimotor与颞叶皮层temporal cortices）以及步态周期阶段（主要为步态总时长的25%-75%），小脑-大脑功能连接的重塑也更为明显。上述结果表明，小脑可介导特定步态周期阶段下感觉运动节律与额中央顶叶连接（fronto-centroparietal）的重塑，这或与生成并调控运动节律的内部计时机制的恢复有关，最终实现步态性能的改善。明确小脑在PD患者步态功能康复中的具体作用，对于制定个体化定制的康复方案至关重要。本次公开的数据集涵盖各步态周期阶段（0-25%、25-50%、50-75%及75-100%）、分组（NMT组与非NMT组）以及评估时间点（TPRE与TPOST）下，显示功能激活的感兴趣区（Regions of Interest, ROIs）局部峰值的时间进程数据。数据展示了步态时段内每个ROI内顶点的最大振幅活动。