HEPAHEALTH I Report Epidemiological and Risk Factors data

The HEPAHEALTH project consists of three related reviews
conducted to summarise the
current epidemiological situation
regarding liver disease in Europe
...to examine trends in risk factors associated
with liver disease and identify potential
interven-tions and policies which could be
effective in reducing the burden of liver disease.
Databases summarising the data collected
were collated.
This report first describes the data collected on
the epidemiological burden of liver diseases in
35 European countries. The most up-to-date
picture of the prevalence of and mortality from
all liver diseases is presented, after which the
contribution of categories of liver disease on the
total burden by country is examined. The focus
then shifts to on historical trends in mortality
and prevalence data, by liver disease category,
Introduction
24
in order to better understand current patterns
in the epidemiological data.
In the second review, the current and historical
patterns in the main modifiable risk factors for
liver disease are summarised: alcohol consumption, obesity and diabetes. The aim was to
understand the association between these risk
factors and liver disease by reviewing the
literature and analysing collected data.
Finally, this project reports on the recent evidence behind the main public health measures
and policies for reducing the burden of liver
disease, through interventions aimed at the
main risk factors for liver disease.
This report also contains several focus sections
in which includes information on the limitations
in data collection are discussed, as well as
a summary of a qualitative interview study
conducted on liver disease experts, in order to

triangulate and supplement findings from the
formal review of databases and the literature.

HEPAHEALTH项目包含三项关联综述，旨在全面梳理当前欧洲肝脏疾病的流行病学现状，探讨肝脏疾病相关危险因素的变化趋势，并识别可有效减轻肝脏疾病负担的潜在干预措施与政策。当前已完成收录所有收集数据的数据库汇编工作。
本报告首先阐述了35个欧洲国家肝脏疾病流行病学负担的相关收集数据，呈现了所有肝脏疾病的最新患病率与死亡率图景；随后分析了各国不同肝脏疾病类别对总疾病负担的贡献占比。此后，研究聚焦于按肝脏疾病类别划分的死亡率与患病率历史变化趋势，以期更深入地理解流行病学数据中的当前模式。
在第二项综述中，本报告梳理了肝脏疾病主要可改变危险因素的当前与历史变化模式，包括饮酒、肥胖与糖尿病。研究旨在通过文献回顾与收集数据分析，明确上述危险因素与肝脏疾病之间的关联。
最后，本项目报告了针对肝脏疾病主要危险因素实施干预措施相关的最新公共卫生措施与政策证据，以助力减轻肝脏疾病负担。
本报告还包含多个专题章节，其中讨论了数据收集过程中存在的局限性，并收录了一项针对肝脏疾病领域专家的定性访谈研究的汇总结果，以通过三角验证法补充来自数据库与文献正式综述的研究发现。