Crystal structure of human TLR8 in complex with Compound 11

Crystal structure of human TLR8 in complex with Compound 11 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methyl-7-(7-methyl-2-piperidin-4-yl-indazol-5-yl)furo[3,2-c]pyridin-4-one, Toll-like receptor 8, ... Authors: Faller, M, Zink, F. Deposit date: 2020-01-15 Release date: 2020-08-12 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.793 Å) Cite: Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay. J.Med.Chem., 63, 2020人源Toll样受体8（Toll-like receptor 8, TLR8）与化合物11复合物的晶体结构 描述组分：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、5-甲基-7-(7-甲基-2-哌啶-4-基-吲唑-5-基)呋喃并[3,2-c]吡啶-4-酮、Toll样受体8（TLR8）…… 作者：Faller M、Zink F 提交日期：2020-01-15 发布日期：2020-08-12 最后修改日期：2024-11-13 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.793埃（Å） 引用文献：《基于靶点的5-吲唑-5-基吡啶酮类Toll样受体7和8拮抗剂的发现与优化：采用生化TLR8拮抗剂竞争实验》，发表于J.Med.Chem.，2020年，第63卷