Acute lithium treatment does not induce NDI in PKCα KO mice.

PKCα KO and WT mice were injected intraperitoneally with 40 mmol/kg LiCl in saline every 24 hours up to 3 or 5 days. Single animals were subsequently placed in individual metabolic cages and urine and serum were collected after 0, 3 or 5 days of daily lithium treatments. Uprot/Uosm = urinary protein/urine osmolality ratio, CrCl/BW = creatinine clearance normalized to body weight (23–25 g). Data are presented as mean ± SEM where * = p<0.05 vs. WT day 0 and § = p<0.05 vs. PKCα KO day 0 is deemed significantly different. n = 6.