Mutations in known Sma/Mab pathway genes specifically suppress the sma-9 M lineage phenotype.

Suppression was scored based on the re-appearance of M-derived CCs, which are missing in sma-9(cc604) mutant. All animals listed in this table are homozygous for sma-9(cc604) except in the case of let-381(RNAi).ND: not determined.a The worms scored are homozygous for sma-9(cc604) and homozygous for the mutation indicated.b The worms scored are homozygous for sma-9(cc604) and heterozygous for the mutation indicated.c Data from [20]. All mutations are apparent null alleles.d Data from [21]. jj4 is an apparent null allele of drag-1.e Data from [22]. e1430 is an apparent null allele of unc-40.f The worms scored are wild-type worms or sma-3(jj3) worms treated with let-381(RNAi) post-embryonically (see Materials and methods). let-381(RNAi) leads to the loss of M-derived CCs [33].g The numbers shown refer to percentages of worms with 2 M-derived CCs, which likely resulted from inefficient let-381(RNAi).Mutations in known Sma/Mab pathway genes specifically suppress the sma-9 M lineage phenotype.本研究以M系来源细胞残体（M-derived CCs）的重现作为抑制效应的评分依据——此类细胞残体在sma-9(cc604)突变体中本应缺失。本表中所列受试动物均为sma-9(cc604)纯合突变体，仅let-381(RNAi)组除外。ND：未确定（not determined）。 a 本次评分的线虫均为sma-9(cc604)纯合突变体，且携带所标注突变的纯合等位基因。 b 本次评分的线虫均为sma-9(cc604)纯合突变体，且携带所标注突变的杂合等位基因。 c 数据引自文献[20]。所有待检突变均为疑似无效等位基因。 d 数据引自文献[21]。jj4为drag-1基因的疑似无效等位基因。 e 数据引自文献[22]。e1430为unc-40基因的疑似无效等位基因。 f 本次评分的线虫为野生型线虫，或是经let-381(RNAi)进行胚胎后期处理的sma-3(jj3)突变线虫（详见材料与方法）。let-381(RNAi)会导致M系来源细胞残体的缺失[33]。 g 表中所示数值为携带2个M系来源细胞残体的线虫所占百分比，该结果大概率源于let-381(RNAi)的低效介导。 已知Sma/Mab信号通路相关基因的突变可特异性抑制sma-9的M谱系表型。