Diabetes Is the Main Factor Accounting for Hypomagnesemia in Obese Subjects

ObjectiveType 2 diabetes (T2DM) and obesity are associated with magnesium deficiency. We aimed to determine whether the presence of type 2 diabetes and the degree of metabolic control are related to low serum magnesium levels in obese individuals. MethodsA) Case-control study: 200 obese subjects [50 with T2DM (cases) and 150 without diabetes (controls)] prospectively recruited. B) Interventional study: the effect of bariatric surgery on serum magnesium levels was examined in a subset of 120 obese subjects (40 with type 2 diabetes and 80 without diabetes). ResultsType 2 diabetic patients showed lower serum magnesium levels [0.75±0.07 vs. 0.81±0.06 mmol/L; mean difference −0.06 (95% CI −0.09 to −0.04); p ConclusionsOur results provide evidence that the presence of diabetes and the degree of metabolic control are essential in accounting for the lower levels of magnesium that exist in obese subjects.2型糖尿病（Type 2 Diabetes Mellitus, T2DM）与肥胖均与镁缺乏存在关联。本研究旨在明确肥胖人群中2型糖尿病的患病状态与代谢控制程度是否与血清镁水平降低相关。 研究方法：A) 病例对照研究：前瞻性招募200名肥胖受试者，其中50名合并2型糖尿病（病例组），150名无糖尿病（对照组）。B) 干预性研究：对120名肥胖受试者亚组开展研究，其中40名合并2型糖尿病，80名无糖尿病，以此评估减重代谢手术（bariatric surgery）对血清镁水平的影响。 研究结果：2型糖尿病患者的血清镁水平更低[0.75±0.07 vs. 0.81±0.06 mmol/L；平均差值为-0.06（95%置信区间（95% Confidence Interval, 95% CI）：-0.09至-0.04）；P值]。 研究结论：本研究结果证实，糖尿病患病状态与代谢控制程度是阐释肥胖人群血清镁水平降低的关键因素。