Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) table for Kidney, v1.7

Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) tables aim to capture the nested kidney structure of<br>anatomical human body parts, the typology of cells, and biomarkers used to identify cell types. The tables are<br>authored and reviewed by an international team of experts. The kidney ASCT+B tables are generated from a variety of<br>publicly available human kidney datasets and from data generated by HuBMAP and KPMP consortia. Most of the markers<br>listed are observed in more than one study or orthogonally validated. Note that these are predicted markers and a<br>single marker to annotate a cell type is not likely sufficient or specific. Therefore, these are just a guide; more<br>accurate annotation should be done using the entire set of enriched genes in a cluster. The cell types shown here are<br>at much higher granularity, although general markers for many of the structures are also shown. There is a tradeoff in<br>uncertainty of cell type annotation with higher granularity, and as spatial validation approaches become more robust,<br>we will be accordingly revising these.

解剖结构、细胞类型及生物标志物（Anatomical Structures, Cell Types, plus Biomarkers，ASCT+B）表旨在涵盖人体解剖部位中肾脏的嵌套结构、细胞类型分类体系，以及用于识别细胞类型的生物标志物。该表由国际专家团队共同撰写并审核。
肾脏ASCT+B表的数据来源于多种公开可用的人类肾脏数据集，以及HuBMAP与KPMP联盟生成的研究数据。表中列出的多数标志物已在多项研究中被观测到，或经过正交验证。
请注意，本次收录的均为预测性标志物，仅依靠单个标志物来注释细胞类型，往往无法满足特异性与充分性要求。因此，本表仅作参考指引；若要实现更精准的细胞类型注释，应结合聚类簇内的全部富集基因进行分析。
尽管本表同时展示了多数解剖结构的通用标志物，但本次呈现的细胞类型分辨率显著更高。细胞类型分辨率越高，其注释的不确定性也随之升高，这是不可避免的权衡取舍。随着空间验证方法日趋成熟完善，我们将对本表内容进行相应修订。