Sevoflurane Sedation Protocol in Children with Cerebral Palsy Undergoing BotulinumToxin-A Injections - DATABASE

Objective: To investigate the safety and efficacy of a protocol based on sevoflurane sedation for the control of pain and agitation during botulinum toxin infiltration in children with cerebral palsy. Design: Retrospective observational study. Setting: Sedations were performed in a tertiary children's hospital from November 2012 to December 2019. Patients: Infiltrations with BoNT-A were carried out under sevoflurane sedation in 75 children with cerebral palsy. Methods: Initially, unconsciousness is achieved by inhaling 8% sevoflurane through a Mapleson-D system, then deep sedation is maintained with a fresh gas mixture with 2.5-4.0% inspired sevoflurane during intramuscular injections. Main Outcome Measurements: Demographic characteristics, clinical and functional characteristics, the effectiveness of sedation, adverse events (AE), and professional satisfaction were reviewed.

研究目的：探讨基于七氟醚（sevoflurane）镇静的方案，用于脑瘫患儿接受肉毒杆菌毒素浸润治疗过程中控制疼痛与躁动的安全性与有效性。
研究设计：回顾性观察研究。
研究场景：2012年11月至2019年12月，所有镇静操作均于某三级儿童医院开展。
研究对象：75例脑瘫患儿在七氟醚镇静下接受A型肉毒毒素（BoNT-A）浸润治疗。
研究方法：首先通过Mapleson-D系统吸入8%浓度的七氟醚诱导意识丧失；随后在肌内注射操作期间，采用含有2.5%~4.0%吸入浓度七氟醚的新鲜气体混合物维持深度镇静。
主要结局指标：对人口统计学特征、临床与功能特征、镇静有效性、不良事件（AE）及专业满意度进行回顾性分析。