Abnormal histological findings - Female, 49 - Tissue image [609073001473801]

This is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 49Clinical description: Cervical dysplasia, HSILGender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XVIII - Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classifiedDiagnosis: Abnormal histological findingsResult of the histopathological examination: Foci of high-grade dysplasia (HSIL / CIN III), located near the transformation zone - IHC: p16 + (block reaction), increased Ki67 index,
present throughout the full thickness of the epithelium. Dysplastic changes do not reach the surgical margin of the endocervix. Features of mature and immature squamous metaplasia and a moderate chronic inflammatory infiltrate.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: CERVIX UTERITissue: ExocervixType of staining: positive/IHCStaining: Not applicableAntibody: p16Technology:Equipment: VS200 OlympusLens: 20xOrganization:Source: Medical University Gdańsk

本数据集为格但斯克医科大学（Medical University Gdańsk）获取并存档于ZMDL-GUMED的子宫颈（CERVIX UTERI）组织样本的组织病理学图像。
该样本图像采用奥林巴斯VS200玻片扫描仪（VS200 Olympus slide scanner）以20倍放大倍率采集，并保存为DICOM格式。
以下为该样本的患者、样本及诊断详细信息：

患者：
年龄：49岁
临床描述：宫颈发育异常，高级别鳞状上皮内病变（High-grade Squamous Intraepithelial Lesion, HSIL）
性别：女性

诊断相关信息：
诊断分类：ICD-10_10-20
分类编码：第十八章——其他未归类的症状、体征及临床和实验室异常发现
诊断结论：组织病理学异常发现
组织病理学检查结果：于转化区附近可见高级别发育异常灶（HSIL/CIN Ⅲ级，Cervical Intraepithelial Neoplasia Ⅲ, CIN Ⅲ）；免疫组化（Immunohistochemistry, IHC）显示p16呈阳性（块反应），Ki67指数升高，且遍布上皮全层。发育异常病变未累及宫颈内手术切缘。可见成熟与未成熟鳞状上皮化生表现，以及中度慢性炎性浸润。

样本相关信息：
样本材质：福尔马林固定石蜡包埋（Formalin-Fixed Paraffin-Embedded, FFPE）样本
采集方式：手术标本
取材部位：女性生殖器官（FEMALE GENITAL ORGANS）
受累器官：子宫颈（CERVIX UTERI）
组织类型：宫颈外膜（Exocervix）
染色类型：免疫组化阳性染色（positive/IHC）
染色方法：无特殊适用方案
所用抗体：p16

成像技术参数：
成像设备：奥林巴斯VS200（VS200 Olympus）
镜头倍率：20倍

所属机构：
来源单位为格但斯克医科大学（Medical University Gdańsk）