Antibody response of CD46-IFNAR mice to immunization with MV-EDIII or MV-EDIII-ectoM.

aCD46-IFNAR mice were inoculated intraperitoneally (i.p.) twice with 105 TCID50 of MV, MV-EDIII or MV-EDIII-ectoM at one month of interval (6 mice/group). bTwo months after the last immunization, mice were inoculated with 107 FFU of DV1 FGA/NA d1d and sera were analyzed 3 weeks after. cAntibody titers were determined by ELISA on pooled heat-inactivated sera collected one month after immunization and DV inoculation. dFRNT50 represents the highest serum dilution that reduced the number of DV focus-forming units (FFU) on Vero cells by at least 50% and eFRNT75 by at least 75%.