Additional file 1 of Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis

Additional file 1: Table S1. Summary of GWAS data. Table S2. Single trait LDSC of LBD, AD, and PD GWAS. Table S3. Genome-wide significant SNPs (Pmtag &lt; 5×10-8) of MTAG results of LBD and functional annotations. Association statistics of these SNPs from LBD GWAS and one-sided and two-sided ASSET analysis were also provided. Table S4. Genomic risk loci identified by FUMA using LBD GWAS. Table S5. Lead SNPs (P &lt; 5×10-8 and r2 &lt; 0.1) of LBD GWAS and MTAG results of LBD. Table S6. Summary of annotations of 2,160 validated SNPs. Table S7. GCTA-COJO analysis results. Table S8. 90% credible sets of 13 genomic risk loci. Table S9. PP4 of SNPs included in colocalization analysis. Table S10. Functional enrichment analysis using GARFIELD. Table S11. Gene-based analysis for MTAG results of LBD (after Bonferroni correction). Table S12. Transcriptome-wide association study using joint tissue imputation models and MTAG results of LBD (after Bonferroni correction in each tissue). Table S13. Candidate genes identified by both GCTA-fastBAT and TWAS. Table S14. Enrichment analysis for 40 candidate genes associated with LBD.附加文件1：表S1。全基因组关联研究（Genome-Wide Association Study, GWAS）数据汇总。表S2。路易体痴呆（Lewy Body Dementia, LBD）、阿尔茨海默病（Alzheimer's Disease, AD）与帕金森病（Parkinson's Disease, PD）的单性状连锁不平衡得分回归（Linkage Disequilibrium Score Regression, LDSC）分析结果。表S3。路易体痴呆（LBD）多性状GWAS分析工具（Multi-Trait Analysis of GWAS, MTAG）结果中全基因组显著单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs，Pmtag < 5×10^-8）及其功能注释。同时提供了上述SNPs在LBD GWAS中的关联统计量，以及单侧、双侧ASSET分析结果。表S4。基于LBD GWAS数据，通过功能注释与基因组关联研究定位注释工具（Functional Mapping and Annotation of Genome-Wide Association Studies, FUMA）鉴定得到的基因组风险位点。表S5。LBD GWAS以及LBD MTAG分析结果中的领先SNPs（P < 5×10^-8且连锁不平衡系数r² < 0.1）。表S6。2160个验证SNPs的注释信息汇总。表S7。GCTA条件联合多SNP分析（GCTA-Conditional & Joint Multi-SNP Analysis, GCTA-COJO）结果。表S8。13个基因组风险位点的90%可信集。表S9。纳入共定位分析（Colocalization Analysis）的SNPs的后验概率4（Posterior Probability 4, PP4）。表S10。基于GARFIELD工具的功能富集分析结果。表S11。经邦费罗尼校正（Bonferroni correction）后的LBD MTAG分析结果的基因水平分析结果。表S12。采用联合组织插补模型与LBD MTAG分析结果的转录组全基因组关联研究（Transcriptome-Wide Association Study, TWAS）结果（每组织均经邦费罗尼校正）。表S13。同时通过GCTA快速贝叶斯关联检验工具（GCTA-fastBAT）与TWAS鉴定得到的候选基因。表S14。与LBD相关的40个候选基因的富集分析结果。