Additional file 2: of Systems-level organization of yeast methylotrophic lifestyle

Comparison of gene regulation in P. pastoris cultivated with methanol/glycerol or glucose as carbon source in chemostat to transcriptomics data obtained in fed batch cultivation with methanol glycerol or glucose as carbon source. Average fold changes and P values of regulation patterns for methanol vs glycerol and methanol vs glucose 1 h our after starting the methanol feed are shown. Average values derive from three biological replicates per condition. Containing the following four sheets: Description: Experimental setup of the fed batch cultivations, description, and discussion of observed similarities and differences in gene regulations. Upregulated_methanol: Comparison of all genes upregulated in P. pastoris cultivated with methanol/glycerol or glucose as carbon source in chemostat to transcriptomics data obtained by analyzing methanol vs glycerol and methanol vs glucose fed batches. Downregulated_methanol: Comparison of all genes downregulated in P. pastoris cultivated with methanol/glycerol or glucose as carbon source in chemostat to transcriptomics data obtained by analyzing methanol vs glycerol and methanol vs glucose fed batches. All_data: Transcriptomics data of Additional file 1 (P. pastoris cultivated with methanol/glycerol or glucose as carbon source in chemostat) compared to transcriptomics data obtained by analyzing methanol vs glycerol and methanol vs glucose fed batches. (XLSX 1178 kb)