EVALUATION OF ANTIDEPRESSANT ACTIVITY IN CENTRAL NERVOUS SYSTEM OF MICE MODEL USING AQUEOUS EXTRACT OF DIGERA MURICATA

The aim of the present study was to evaluate some effects of Digera muricata (DM) on centralnervous system. The effects of Aqueous Extracts of Digera muricata (AEDM) tested withNeuropharmacological activities like acute toxicity, spontaneous motor activity, exploratory behavioralpattern, marble burying and tail suspension tests were studied in Albino mice. In acute toxicity mice wereadministered with AEDM and MEDM doses orally at 50, 100 and 200 mg/kg body weightintraperitoneally respectively, were tested in mice using different standards like 4 mg diazepam/kg, 3 mgchlorpromazine and 3 mg imipramin/kg -induced sleep test.