Fig 7: Thalamocortical fEPSP amplitude measured before and after prolonged periods of sleep or wake

(A) Hypnograms showing an example of a wake (left) and sleep (right) dense epoch, with flanking periods of the opposite state. Grey rectangles indicate when measurements were taken for comparison. (B) Example fEPSP waveforms before and after a wake (left) or sleep (right) dense epoch. (C) Normalized change in fEPSP amplitude after wake or sleep (wake change, p>0.9; sleep change, p>0.9; Wilcoxon signed-rank test). (D) Correlative plot of duration of wake dense epoch against normalized change in fEPSP amplitude. Black line = linear fit; R2 value and p value included on plot. Inset in top right is an expansion of plot between 0 and 3.5 hours. (E) Same as (D) but for sleep dense. N = 39 wake dense epochs, 55 sleep dense epochs, 4 animals.

(A) 睡眠描记图（Hypnograms）示例：左侧展示觉醒密集时段，右侧展示睡眠密集时段，两侧紧邻相反状态的时段。灰色矩形框标注了用于对比的测量时段。(B) 觉醒密集时段（左）与睡眠密集时段（右）前后的场兴奋性突触后电位（field excitatory postsynaptic potential, fEPSP）波形示例。(C) 觉醒或睡眠密集时段后场兴奋性突触后电位幅值的归一化变化量（觉醒变化组，p>0.9；睡眠变化组，p>0.9；威尔科克森符号秩检验）。(D) 觉醒密集时段持续时长与场兴奋性突触后电位幅值归一化变化量的相关性散点图。黑色实线为线性拟合曲线，图中标注了决定系数R²与p值。右上角内嵌图为0至3.5小时区间的散点图放大版本。(E) 与(D)内容一致，但针对睡眠密集时段。本实验共纳入39个觉醒密集时段、55个睡眠密集时段，实验动物为4只。