Long Non-coding RNA expression predictive of tumour response in patients treated with preoperative chemoradiotherapy for LARC

Neoadjuvant chemoradiotherapy (CRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, there are no good predictive methods. This study investigated whether specific lncRNA expression is associated with response to CRT. Tissue biopsies were obtained from patients before CRT. LncRNA expression was analyzed using one-color microarrays technique comparing signatures between good respondersand poor responders, as measured by tumour regression grade (TRG). Tissue biopsies were obtained from patients before CRT. A total of 3 good response and 3 poor response both for LncRNA and gene expression experiments.