Bace1 with the aminohydantoin Compound R-58

Bace1 with the aminohydantoin Compound R-58 Descriptor: (5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one, Beta-secretase 1 Authors: Olland, A.M, Chopra, R. Deposit date: 2009-08-12 Release date: 2010-03-02 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors. J.Med.Chem., 53, 2010

本数据集针对Bace1（BACE1）构建，包含氨基乙内酰脲类化合物R-58的结构描述符：(5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one，对应的靶点为β-分泌酶1（Beta-secretase 1）。作者：Olland, A.M.、Chopra, R.。提交日期：2009-08-12；发布日期：2010-03-02；最后修改日期：2024-10-16。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.8埃）。引用文献：《5,5'-二取代氨基乙内酰脲类强效选择性人β-分泌酶（BACE1）抑制剂的设计与合成》，刊载于《Journal of Medicinal Chemistry》（缩写J.Med.Chem.），2010年，第53卷。