Orally Absorbed Derivatives of the β‑Lactamase Inhibitor Avibactam. Design of Novel Prodrugs of Sulfate Containing Drugs
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https://figshare.com/articles/dataset/Orally_Absorbed_Derivatives_of_the_Lactamase_Inhibitor_Avibactam_Design_of_Novel_Prodrugs_of_Sulfate_Containing_Drugs/7294709
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资源简介：
Only one FDA-approved
β-lactamase inhibitor has ever been
orally available: clavulanic acid, approved in 1984. Avibactam, approved
by FDA in 2015, is the first of a new class of BLIs called diazabicyclooctanes,
or “DBOs”. This class has much broader coverage than
clavulanic acid but can only be administered by intravenous injection.
Herein, we describe the synthesis and testing of the first approved
BLI to be rendered orally bioavailable since clavulanic acid (1984).
创建时间：
2018-11-03
