Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298

Protein Data Bank Japan2025-05-21 更新2026-03-28 收录

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Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 Descriptor: 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ... Authors: Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. Deposit date: 2022-01-30 Release date: 2023-05-17 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023

人源M4毒蕈碱型乙酰胆碱受体与Gi1蛋白、激动剂伊哌克辛(iperoxo)以及正变构调节剂LY2033298形成的复合物标识符：3-氨基-5-氯-N-环丙基-6-甲氧基-4-甲基噻吩并[2,3-b]吡啶-2-甲酰胺、4-(4,5-二氢-1,2-恶唑-3-基氧基)-N,N,N-三甲基丁-2-炔-1-铵、抗体片段scFv16，…… 作者：Vuckovic Z、Mobbs J.I、Belousoff M.J、Glukhova A、Sexton P.M、Danev R、Thal D.M 存档日期：2022-01-30 发布日期：2023-05-17 最后修改日期：2025-05-21 方法：电子显微镜（2.4 Å）引用：《M4毒蕈碱型乙酰胆碱受体变构调节的结构与动态机制》，《Elife》，2023年

创建时间：

2022-01-30