Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice

High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. The liver, gastrocnemius muscle, brain, and epididymal white adipose tissue (WAT) were collected for analysis of gene expressions. FR attenuated inflammation in the liver, brain, and gastrocnemius muscle but did not markedly change inflammatory gene expression in epididymal WAT. We concluded that adipose tissue was less responsive to FR in terms of gene expression of pro-inflammatory and anti-inflammatory genes.

高能量摄入可诱发慢性炎症、胰岛素抵抗及2型糖尿病等慢性疾病，而食物限制（Food Restriction, FR）能够对上述病症起到预防作用。本研究对比了食物限制（FR）对脂肪组织、肝脏、肌肉及大脑中促炎基因与抗炎基因表达的影响。将雄性瑞士小鼠分为两组：食物限制组（FR组）与自由摄食对照组，干预周期共计56天。收集肝脏、腓肠肌、大脑及附睾白色脂肪组织（Epididymal White Adipose Tissue, WAT）用于基因表达分析。结果显示，食物限制可缓解肝脏、大脑及腓肠肌的炎症反应，但对附睾白色脂肪组织内的炎症基因表达无显著调控效果。本研究得出结论：就促炎与抗炎基因的表达而言，脂肪组织对食物限制的响应性较弱。