Association Between HLA Polymorphisms and Sympathetic Ophthalmia in Han Chinese

Sympathetic ophthalmia (SO) is considered as an autoimmune disease with unclear mechanisms. This study investigated the relationship between HLA polymorphisms and SO. HLA typing was performed using the LABType reverse SSO DNA typing method. The allele and haplotype frequencies were assessed using the PyPop software. Statistical significance of genotype distributions between 116 patients and 84 healthy individuals (control) was determined using Fisher’s exact test or Pearson's chi-squared test. The SO group had a higher frequency of <i>HLA-DRB1 * 04:05</i>, <i>HLA-DQB1</i> * 04:01, <i>DRB1 * 04:05-DQB1 * 04:01 haplotype</i>   as compared to the control group (Pc &lt; 0.001 for all). This study revealed that <i>DRB1 * 04:05</i> and <i>DQB1 </i>*<i> 04:01</i> alleles, as well as <i>DRB1 * 04:05-DQB1 * 04:01</i> haplotye could be potential risk factors for SO.