Avermectins residues in milk produced in the state of Pernambuco

Abstract Milk is a food widely consumed by the population, so it is important that it has adequate hygienic conditions and is free of chemical contaminants from various sources. This study aimed to evaluate the occurrence of avermectin residues in milk produced in the state of Pernambuco. The collections were performed in the dry and rainy season, being collected 60 and 48 samples, respectively, which were analyzed in the National Agricultural Laboratory of Rio Grande do Sul by liquid chromatography coupled with mass spectrometry. In the dry period, 46.7% (28/60) of samples with avermectin residues above the Limit of Detection (LD), 1.7% (01/60) with levels above the Quantifiable Limit (QL) and 51.6% (31/60) did not detect any residues. In the rainy season, 6.25% (03/48) presented residues above LD and in 93.75% (45/48) of samples there was no detection of residues. No samples were detected with amounts of avermectins above the Maximum Residue Limit in this study. The milk evaluated did not expose high risks to the health of the population, due to the low level of residues present. However, veterinary drug residue monitoring data are essential for assessing human exposure to these compounds.

摘要 牛奶是大众广泛食用的食品，因此其具备合格的卫生条件且不含各类来源的化学污染物至关重要。本研究旨在评估伯南布哥州（Pernambuco）生产的牛奶中阿维菌素（avermectin）残留的检出情况。样本分别于旱季和雨季采集，其中旱季采集60份、雨季采集48份，所有样本均通过液相色谱-质谱联用法（liquid chromatography coupled with mass spectrometry）在南里奥格兰德州国家农业实验室完成检测。
旱季样本中，46.7%（28/60）的阿维菌素残留量高于检出限（Limit of Detection, LD），1.7%（1/60）的残留量高于定量限（Quantifiable Limit, QL），剩余51.6%（31/60）未检出任何残留。雨季样本中，6.25%（3/48）的残留量高于检出限，93.75%（45/48）未检出任何残留。
本研究未发现阿维菌素残留量超过最大残留限量（Maximum Residue Limit, MRL）的样本。本次评估的牛奶因残留水平较低，未对人群健康构成显著风险。然而，兽药残留监测数据对于评估人体接触此类化合物的暴露风险至关重要。