Supplemental Materials for "Colocalization and functional analyses identify GBE1 as a gene linking muscle strength and cardiometabolic fitness"

SUPPLEMENTAL MATERIALSupplemental Table S1: Colocalization pipeline resultsSupplemental Table S2: DEG_GBE1_v_NT_control.csvSupplemental MethodsSupplemental Figure S1: Correlation of the Handgrip Strength GWAS with the GBE1 eQTL.Supplemental Figure S2: Western blot of oxidative phosphorylation proteins in GBE1 knockdown and non-targeting control muscle cell lysates.Supplemental Figure S3: Phenome wide association of common variants in the GBE1 locus.Supplemental Video S1: Live cell holotomographic imaging of Non-targeting control cellsSupplemental Video S2: Live Cell holotomographic imaging of GBE1 KD cells补充材料 补充表S1：共定位分析流程结果 补充表S2：差异表达基因（Differentially Expressed Gene, DEG）GBE1与非靶向对照（non-targeting control, NT control）对比数据集.csv 补充方法 补充图S1：握力全基因组关联研究（Genome-Wide Association Study, GWAS）与GBE1表达数量性状位点（expression Quantitative Trait Locus, eQTL）的相关性分析 补充图S2：GBE1敲低（knockdown, KD）组与非靶向对照组肌肉细胞裂解液中氧化磷酸化相关蛋白的蛋白质免疫印迹（Western Blot）结果 补充图S3：GBE1基因座常见变异的表型组全关联分析 补充视频S1：非靶向对照细胞的活细胞全息断层成像 补充视频S2：GBE1敲低（KD）细胞的活细胞全息断层成像