Histopathological and biochemical changes during kidney injury in C. porcellus infected with T. cruzi.

aParasites in kidney were detected by H&E and PCR. In order to be considered positive one or more parasites needed to be observed in two entire tissue sections.bCorresponds to the increase of level of two or more biochemical parameters: serum urea, urine proteins and urine KIM-1.n = Number of animals analyzed.a. 采用苏木精-伊红（Hematoxylin & Eosin, H&E）染色法与聚合酶链式反应（Polymerase Chain Reaction, PCR）检测肾脏组织内的寄生虫；若判定为阳性结果，则需在两张完整的组织切片中观察到至少1个寄生虫。 b. 指两项及以上生化指标水平升高：血清尿素、尿蛋白与尿肾损伤分子1（Kidney Injury Molecule-1, KIM-1）。 n = 所分析的动物数量。