Myrifabine, the First Dimeric Myrioneuron Alkaloid from Myrioneuron faberi

One Myrioneuron alkaloid, myrifabine (1), the first example of a dimer with 12 chiral centers embraced in a decacyclic novel skeleton, was isolated from Myrioneuron faberi. Its structure was elucidated by spectroscopic data and single-crystal X-ray diffraction. The antimicrobial and cytotoxic activities of 1 were evaluated in vitro.本研究从菲岛琼楠（Myrioneuron faberi）中分离得到一种琼楠属生物碱——myrifabine（1），其为首个拥有12个手性中心且具有十环新颖骨架的二聚体类化合物。通过波谱学数据与单晶X射线衍射（single-crystal X-ray diffraction）技术解析了该化合物的化学结构。体外评价了化合物1的抗菌活性与细胞毒活性。