PI3Kg in complex with AZD6482

PI3Kg in complex with AZD6482 Descriptor: 2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM Authors: Giordanetto, F, Barlaam, B, Berglund, S, Edman, K, Karlsson, O, Lindberg, J, Nylander, S, Inghardt, T. Deposit date: 2014-06-30 Release date: 2014-10-22 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discovery of 9-(1-Phenoxyethyl)-2-Morpholino-4-Oxo-Pyrido[1, 2-A]Pyrimidine-7-Carboxamides as Oral Pi3Kbeta Inhibitors, Useful as Antiplatelet Agents. Bioorg.Med.Chem.Lett., 24, 2014

PI3Kγ（PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM，磷脂酰肌醇4,5-二磷酸3-激酶催化亚基γ亚型）与AZD6482形成的复合物，配体化学结构描述符：2-[[(1R)-1-(7-甲基-2-吗啉-4-基-4-氧代吡啶并[1,2-a]嘧啶-9-基)乙基]氨基]苯甲酸。作者：Giordanetto, F、Barlaam, B、Berglund, S、Edman, K、Karlsson, O、Lindberg, J、Nylander, S、Inghardt, T。提交日期：2014-06-30。发布日期：2014-10-22。最后修改日期：2024-01-10。检测方法：X射线衍射（分辨率2.9 Å）。引用文献：《作为抗血小板药物的口服PI3Kβ抑制剂：9-(1-苯氧基乙基)-2-吗啉基-4-氧代吡啶并[1,2-a]嘧啶-7-甲酰胺类的发现》，《Bioorg.Med.Chem.Lett.》，2014年，第24卷。