Suplementary data.docx

The strategy presented in the current work is a proof-of-concept for future vaccine candidate design bypassing the need for an external toxoid coupling and for growing large amounts of pathogens to isolate lipopolysaccharides. If the candidate is confirmed to offer protection in an animal model of periodontosis, the design of future vaccines could be performed faster and more safely for many other pathogens, Select Agents included. Preparation for animal verification of the proposed periodontosis vaccine candidate is in progress.