Fibrosis and cirrhosis of liver - Male, 53 - Tissue image [6220730015165611]

This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 53Clinical description: Liver fibrosis. Congenital haemochromatosis.Gender: MaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XI - Diseases of the digestive systemDiagnosis: Fibrosis and cirrhosis of liverResult of the histopathological examination: In the examined oligopyoptate (one partially fragmented section) fragments of the enlarged biliary spaces are usually present, containing a large number of inflammatory cells, mainly mononuclear. Within the above-mentioned enlarged spaces, there are features of pronounced fibrogenesis, characterized by intense portal and periportal fibrosis with the formation of portal-portal fibrous bridges, it is possible that also portal-central, with the presence of a single regenerative nodule. In some portal spaces accumulating elements of collagen connective tissue, there is a clear proliferation of bile ducts. Large groups of enlarged hepatocytes are observed, especially those located near the portal spaces, depositing iron in the form of haemosiderin, and stimulated Borowicz-Kupffer cells accumulating hemosiderin. In places, there are features of mixed steatosis of quite numerous hepatocytes, with a predominance of large droplets. The microscopic image of the examined material indicates the process of intense fibrosis of on the base of congenital haemochromatosis, although coexistence of another liver pathology cannot be ruled out.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: LIVER AND INTRAHEPATIC BILE DUCTSTissue: LiverType of staining: positive/HCStaining: Masson-GoldnerAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk

本数据集为格但斯克医科大学采集并存档于ZMDL-GUMED的肝脏及肝内胆管组织样本的组织病理学图像。
该样本图像采用Pannoramic 250 3DHistech玻片扫描仪以20倍放大倍率采集，并存储为DICOM格式。
患者、样本及诊断的详细信息如下：
患者：年龄53岁，临床特征为肝纤维化、先天性血色素沉着症，性别为男性。
诊断分类：ICD-10_10-20分类，分类编码为第十一章——消化系统疾病，诊断结论为肝纤维化与肝硬化。
组织病理学检查结果：本次送检的少量切片（含1份部分碎裂的切片）中，通常可见扩张的胆管腔隙碎片，内含大量炎性细胞，以单核细胞为主。上述扩张的腔隙内可见显著的纤维组织增生特征：表现为明显的门管区及门管周围纤维化，形成门管-门管纤维桥接，亦可见门管-中央静脉纤维桥接，可见单个再生结节。部分门管区可见胶原结缔组织成分聚集，胆管上皮明显增生。可见大量肿大的肝细胞群，尤以门管区附近的肝细胞为著，该类细胞以铁血黄素（haemosiderin）的形式沉积铁离子，活化的博罗维茨-库普弗细胞（Borowicz-Kupffer cell）可蓄积铁血黄素。部分区域可见多发肝细胞混合性脂肪变性，以大滴状脂肪变性为主。送检样本的显微镜图像提示，基于先天性血色素沉着症的重度纤维化进程，但不能排除合并其他肝脏病变的可能。
样本详情：
样本材质：福尔马林固定石蜡包埋（Formalin-Fixed Paraffin-Embedded, FFPE）
采集方式：手术标本
解剖部位：消化系统器官
所属器官：肝脏及肝内胆管
组织类型：肝脏
染色类型：阳性/HC染色
染色方法：Masson-Goldner染色
所用抗体：无适用抗体
技术与设备：Pannoramic 250 3DHistech
镜头放大倍率：20x
来源机构：格但斯克医科大学