Dataset for COVID CD8+ T cell Epitope Paper

In this bioinformatics-based study, we explored the CD8+ epitope diversity estimated 27 of the most common HLA-A and -B alleles, representing most of the United States population. Analysis of 16 SARS-CoV-2 variants (2 Alpha (B.1, B.1.1.7), 5 Delta (AY.100, AY.25, AY.3, AY.3.1, AY.44), and 9 Omicron (BA.1, BA.1.1, BA.2, BA.4, BA.5, BQ.1, BQ.1.1, XBB.1, XBB.1.5)) in analyzed MHC Class I alleles revealed SARS-Cov-2 CD8+ epitope conservation was estimated at 87.6-96.5% in spike (S), 92.5-99.6% in membrane (M), and 94.6-99% for nucleocapsid (N).

本项基于生物信息学的研究，针对占美国总人口绝大多数的27种最常见的人类白细胞抗原（HLA）-A与HLA-B等位基因，对CD8+表位（CD8+ epitope）多样性展开了探究。本研究对16株新型冠状病毒（SARS-CoV-2）变异株（包含2株阿尔法（Alpha）变异株：B.1、B.1.1.7；5株德尔塔（Delta）变异株：AY.100、AY.25、AY.3、AY.3.1、AY.44；以及9株奥密克戎（Omicron）变异株：BA.1、BA.1.1、BA.2、BA.4、BA.5、BQ.1、BQ.1.1、XBB.1、XBB.1.5）与所分析的主要组织相容性复合体（MHC）I类等位基因进行分析后发现，新型冠状病毒CD8+表位的保守性在刺突蛋白（S）中为87.6%~96.5%，在膜蛋白（M）中为92.5%~99.6%，在核衣壳蛋白（N）中为94.6%~99%。