Supplemental Material: Environmental Pollutants and Diseases

The data that support the findings of this systematic review are provided in the supplementary materials. Supplemental Material 1 contains a detailed list of keywords and Boolean search strategies applied in the literature search across PubMed, Scopus, and ScienceDirect databases. It outlines the structured search approach used to identify relevant studies on environmental pollutant exposure and genetic or immunological diseases. Supplemental Material 2 presents the results of the critical appraisal using the JBI checklist, encompassing cross-sectional, cohort, and case-control studies. This includes a systematic evaluation of study quality, covering aspects such as ; environmental pollutants; genetic; heavy metals; immunological diseases.; environmental pollutants; genetic; heavy metals; immunological diseases.validity of exposure measurement, confounding factor management, and appropriateness of statistical analysis. Together, these materials ensure transparency and replicability of the review process. Additional data, such as full data extraction tables or ROBINS-E risk of bias assessments, are available from the corresponding author upon reasonable request.

支撑本系统综述研究结论的数据已收录于补充材料中。补充材料1详细罗列了在PubMed、Scopus及ScienceDirect数据库开展文献检索时所采用的关键词清单与布尔检索策略，阐明了用于筛选环境污染物暴露与遗传或免疫性疾病相关研究的结构化检索方法。补充材料2展示了采用JBI量表（JBI checklist）进行批判性评价的结果，涵盖横断面研究、队列研究及病例对照研究，其中包含对研究质量的系统性评估，涉及暴露测量有效性、混杂因素管控以及统计分析方法的适用性等维度。上述材料共同保障了本综述流程的透明度与可重复性。如需获取完整数据提取表、ROBINS-E偏倚风险评估等额外数据，可在提出合理申请后向通讯作者索取。