White Matter Hyperintensities Evolution Patterns 1 Year Post-lacunar Stroke and their association with post-stroke cognition

Lacunar strokes are a common type of ischemic stroke. They are associated with long-term disability, but the factors affecting the dynamic of the infarcted lesion and the brain imaging features associated with them, reflective of small vessel disease (SVD) severity, are still largely unknown. We investigated whether the distribution, volume and 1-year evolution of white matter hyperintensities (WMH), one of these SVD features, relate to the extent and location of these infarcts, accounting for vascular risk factors and to cognition 1 and 3 years after the stroke. This dataset contains the scripts and the voxel-wise results from our investigations in patients [n = 118, mean age 64.9 (SD 11.75) years old] who presented to a regional hospital with a lacunar stroke syndrome within the years 2010 and 2013 and consented to participate in a study of stroke mechanisms.

腔隙性脑梗死（Lacunar strokes）是缺血性脑卒中的常见类型，其与长期残疾存在关联，但目前影响梗死病灶动态变化的相关因素，以及与腔隙性脑梗死相关、反映小血管病（SVD）严重程度的脑影像学特征，仍尚未完全明确。本研究探讨了作为小血管病特征之一的脑白质高信号（WMH）的分布、体积及1年演变情况，是否与此类梗死灶的范围和位置存在关联，并在校正血管危险因素后，分析其与卒中后1年及3年认知功能的相关性。本数据集收录了针对2010至2013年间于某区域医院就诊的118例腔隙性脑梗死综合征患者（平均年龄64.9岁，标准差SD 11.75）开展的上述研究的脚本文件与体素层面分析结果；所有受试者均签署知情同意，参与该项卒中机制研究。