Meta-analysis of individual and combined effects of mycotoxins on growing pigs

ABSTRACT Little is known about the toxicity of concomitantly occurring mycotoxins in pig diets. This study was conducted to evaluate, through meta-analysis, the individual and the combined effects of mycotoxins on pig performance. The meta-analysis followed three sequential analyses (graphical, correlation, and variance-covariance) based on a database composed of 85 published papers, 1,012 treatments and 13,196 animals. Contamination of diets with individual mycotoxins reduced (p < 0.05) feed intake by 14 % and weight gain by 17 %, while combined mycotoxins reduced the same responses by 42 % and 45 %, respectively, in comparison with the non-challenged group. The correlation (p < 0.05) between reduction in weight gain (ΔG) and reduction in feed intake (ΔFI) was 0.67 in individual challenges and 0.93 in combined challenges. The estimated ΔG was –6 % in individual challenges and –7 % in combined challenges when ΔFI was zero, suggesting an increase in the maintenance requirements of challenged animals. Most of ΔG (58 % in individual challenges and 84 % in combined challenges) was attributed to the changes in feed efficiency. The association of mycotoxins enhances individual toxic effects and the ΔFI is important in explaining the deleterious effects on the growth of challenged pigs.

摘要：目前学界对猪日粮中同时存在的真菌毒素（mycotoxins）的联合毒性了解甚少。本研究通过荟萃分析（meta-analysis），评估单一及复合真菌毒素对猪生产性能的影响。本次荟萃分析基于包含85篇已发表文献、1012个处理组与13196头试验动物的数据库，依次开展三类分析：图形分析、相关性分析及方差-协方差分析。与未攻毒组相比，日粮受单一真菌毒素污染会使猪的采食量降低14%、日增重降低17%（p < 0.05）；而日粮受复合真菌毒素污染时，上述两项指标分别降低42%与45%。在单一毒素攻毒组中，日增重降幅（ΔG）与采食量降幅（ΔFI）之间的相关系数为0.67（p < 0.05），复合毒素攻毒组则为0.93。当采食量降幅为0时，单一毒素攻毒组估算的日增重降幅为-6%，复合毒素攻毒组为-7%，这表明攻毒试验动物的维持代谢需求有所升高。日增重降幅的大部分（单一毒素攻毒组为58%，复合毒素攻毒组为84%）可归因于饲料转化率的变化。真菌毒素的复合存在会增强单一毒素的毒性效应，而采食量降幅是解释攻毒猪生长受抑制有害效应的重要指标。