Structural characterization of Silver complexes based on ester derivatives of bis(pyrazol-1-yl)acetate ligands

This projects aims to elucidate the local structure on a series of Silver and Copper complexes based on ester derivatives of bis(pyrazol-1-yl)acetate ligands and stabilized with tri-n-butylphosphine or 1,3,5-triaza-7-phosphaadamantane ligands. These complexes are promising candidates in the field of biomedicine and specifically in cancer treatment. Previous data acquired on different cancerous cell lines proved the effectiveness of the treatment, inducing paraptotic cell death and showing higher citotoxicity that the reference metallodrug cisplatin. In this context our group aims to study the local coordination in these Silver complexes in view of a future application as both standalone drugs and/or in pairing with a drug delivery vector such as gold nanoparticles and nanorods.

本项目旨在阐明一系列以双(吡唑-1-基)乙酸酯配体的酯衍生物为配体、并经三正丁基膦(tri-n-butylphosphine)或1,3,5-三氮杂-7-磷杂金刚烷配体(1,3,5-triaza-7-phosphaadamantane ligands)稳定的银与铜配合物的局部结构。该类配合物在生物医学领域，尤其是癌症治疗方向极具应用前景。此前针对不同癌细胞系获取的实验数据证实了该类配合物的治疗有效性：其可诱导副凋亡性细胞死亡，且细胞毒性优于参比金属药物顺铂(cisplatin)。在此研究背景下，本团队旨在探究此类银配合物的局部配位特征，以期未来将其开发为单一治疗药物，或与金纳米颗粒(gold nanoparticles)、纳米棒(nanorods)等药物递送载体联用。