Genomic signature for malignant tumour progression in cervical cancer

To investigate the clinical genomic signatures associated with tumor progression, we performed genomic sequencing on patients with cervical cancer, including primary, recurrent, and metastatic tumor tissues, and obtained their somatic mutation and copy number alteration profiles.为探究与肿瘤进展相关的临床基因组特征，我们对宫颈癌患者的原发性、复发性及转移性肿瘤组织开展了基因组测序，并获取了其体细胞突变与拷贝数变异谱。