Additional file 1 of Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma

Additional file 1: Supplementary text. Detailed research methods. Supplementary Fig. 1. PPI and cluster of hyper-modified DHMPs. Supplementary Fig. 2. PPI and cluster of hypo-modified DHMPs. Supplementary Table 1. Statistics of Mass Spectrometry Data. Supplementary Table 2. Clinical characteristics of OACC patients. Supplementary Table 3. Go enrichment analyses of differentially expressed proteins. Supplementary Table 4. KEGG pathway enrichment of differentially expressed proteins. Supplementary Table 5. Go enrichment analyses of differentially expressed and 2-hydroxyisobutyrylated modified proteins. Supplementary Table 6. KEGG pathway enrichment of differentially expressed and 2-hydroxyisobutyrylated modified proteins. Supplementary Table 7. Top 10 hub proteins in hyper-and hypo modified DHMPs based on degree. Supplementary Table 8. KEGG enrichment in up cluster 1–6. Supplementary Table 9. KEGG enrichment in down cluster 1–2. Supplementary Table 10. The Khib of glycolysis pathway enzyme.

附加文件1：补充文本。详细研究方法。
补充图1：高修饰差异修饰蛋白（DHMPs）的蛋白质相互作用（Protein-Protein Interaction，PPI）与聚类结果
补充图2：低修饰差异修饰蛋白（DHMPs）的蛋白质相互作用（Protein-Protein Interaction，PPI）与聚类结果
补充表1：质谱数据统计结果
补充表2：口腔腺样囊性癌（Oral Adenoid Cystic Carcinoma，OACC）患者的临床特征
补充表3：差异表达蛋白的基因本体（Gene Ontology，GO）富集分析结果
补充表4：差异表达蛋白的京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes，KEGG）通路富集分析结果
补充表5：差异表达且经2-羟基异丁酰化修饰的蛋白的基因本体（GO）富集分析结果
补充表6：差异表达且经2-羟基异丁酰化修饰的蛋白的京都基因与基因组百科全书（KEGG）通路富集分析结果
补充表7：基于节点度值的高、低修饰差异修饰蛋白（DHMPs）中的前10位枢纽蛋白
补充表8：上调聚类1-6的京都基因与基因组百科全书（KEGG）富集分析结果
补充表9：下调聚类1-2的京都基因与基因组百科全书（KEGG）富集分析结果
补充表10：糖酵解通路相关酶的赖氨酸2-羟基异丁酰化（Lysine 2-hydroxyisobutyrylation，Khib）修饰信息